When combination therapy is appropriate
And while proprietary blends are sadly not uncommon in nootropics (and Alpha BRAIN isnt the worst offender, at least breaking down their blend into three separate smaller blends), it isnt something that gives us confidence, and it cost Onnit a recommendation from us in this context
Cited studies PMID 40277822 "Benchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism" (Journal of Clinical Endocrinology & Metabolism, 2025)
Hu P, An J, Faulkner MM, Wu H, Li Z, Tian X, Giraldo JP
Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver
Severe liver disease may reduce IGF-1 synthesis (blunting downstream effects) but does not prolong the peptide's presence in circulation